Back to results
US 10,647,689 B2Granted
Apelin receptor agonists and methods of use thereof
AssigneeSanford Burnham Prebys Medical Discovery Institute
InventorsLayton H. Smith, Anthony B. Pinkerton, Paul Hershberger, Patrick Maloney, Danielle McAnally
Life of this patent
Estimating the term…
Abstract
Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.
Claims10
A compound of structural Formula I, or a pharmaceutically acceptable salt, polymorph, solvate, tautomer, or N-oxide thereof:
- wherein:
- X is selected from the group consisting of S, O, and NR9;
- A is selected from the group consisting of substituted phenoxy, optionally substituted aniline, and substituted 5- or 6-membered heteroaryl or heteroaryl-oxy;
- B is selected from the group consisting of H, optionally substituted aryl, optionally substituted alkoxy, optionally substituted phenoxy, optionally substituted amino, optionally substituted aniline, and optionally substituted 5- or 6-membered heteroaryl or heteroaryl-oxy;
- wherein the optionally substituted aniline of A or B is attached to the parent molecule through a nitrogen atom;
- each R1-R9 is independently selected from the group consisting of hydrogen, halogen, —CN, —C(O)—N(R10)—R11, —C(O)—O—R12, —SO2R13 optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, optionally substituted amino, and optionally substituted 5- or 6-membered heteroaryl;
- each R10-R13 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, optionally substituted amino, and optionally substituted 5- or 6-membered heteroaryl;
- and
- Z is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl.
6 more elements
A compound of structural Formula II, or a pharmaceutically acceptable salt, polymorph, solvate, tautomer, or N-oxide thereof:
- wherein:
- X is selected from the group consisting of S, O and NR9;
- A is selected from the group consisting of substituted phenoxy, optionally substituted aniline, and substituted 5- or 6-membered heteroaryl or heteroaryl-oxy;
- B is selected from the group consisting of H, optionally substituted aryl, optionally substituted alkoxy, optionally substituted phenoxy, optionally substituted amino, optionally substituted aniline, and optionally substituted 5- or 6-membered heteroaryl or heteroaryl-oxy;
- wherein the optionally substituted aniline of A or B is attached to the parent molecule through a nitrogen atom;
- Y1 is CR14;
- each Y2-Y9 are independently selected from the group consisting of N and CR14;
- each R14 is independently selected from the group consisting of hydrogen, halogen, —CN, —C(O)—N(R15)—R16, —C(O)—O—R17, —SO2R18 optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl;
- each R15-R18 is independently selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl;
- and
- Z is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl.
8 more elements
A compound selected from the group consisting of:
- methyl 4-{[N-(5,6-dimethoxybenzothiazol-2-yl)carbamoyl]methyl}benzoate, methyl 3-{[N-(5,6-dimethoxybenzothiazol-2-yl)carbamoyl]methyl}benzoate, 3-{[N-(5,6-dimethoxybenzothiazol-2-yl)carbamoyl]methyl}benzoic acid, 4-{[N-(5,6-dimethoxybenzothiazol-2-yl)carbamoyl]methyl}benzoic acid, 2-{[N-(5,6-dimethoxybenzothiazol-2-yl)carbamoyl]methyl}benzoic acid, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]propanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]butanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-3-methylbutanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[3-(N,N-dimethylcarbamoyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(N,N-dimethylcarbamoyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{4-[(dimethylamino)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-4-methoxybutanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-3-cyclopropyl-2-[4-(ethylsulfonyl)phenyl]propanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-3-phenylpropanamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[2-(N,N-dimethylcarbamoyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[3-(ethylsulfonyl)phenyl]acetamide, N-(2H-1,3-dioxolano[4,5-e]benzothiazol-7-yl)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl){[4-(ethylsulfonyl)phenyl]cyclopropyl}carboxamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-cyclopentyl-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(7H,8H-1,4-dioxano[5,6-e]benzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-[5-(diethylamino)benzothiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{3-[(4-fluorophenyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{4-[(cyclopropylmethyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(cyclopentylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-methoxyacetamide, N-(5,6-dimethoxybenzimidazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(dimethylamino)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-piperidylacetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-morpholin-4-ylacetamide, N-(5,6-dimethoxybenzoxazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{4-[(2-methoxyethyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{3-[(methylethyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{3-[(cyclopropylmethyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[3-(cyclopentylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(2-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(3-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-[4-(trifluoromethyl)phenoxy]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(methylethoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-propoxyacetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-cyclopentyloxy-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-cyclohexyloxy-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(3-methylbutoxy)acetamide, 2-[4-(ethylsulfonyl)phenyl]-N-[6-(4-methylpiperazinyl)benzothiazol-2-yl]acetamide, 2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)-N-[6-(4-methylpiperazinyl)benzothiazol-2-yl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{2-[(4-fluorophenyl)sulfonyl]phenyl}-2-(4-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[3-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methylphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-chlorophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(2-methylphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(2-chlorophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(phenylmethoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(2-methylpropoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(3-methylbut-2-enyloxy)acetamide, 2-(2H-3,4,5,6-tetrahydropyran-4-yloxy)-N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(7H,8H-1,4-dioxano[5,6-g]benzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, N-(7H,8H-1,4-dioxano[5,6-g]benzothiazol-2-yl)-2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, 2-[4-(ethylsulfonyl)phenyl]-N-(6-methoxybenzothiazol-2-yl)-2-(4-methoxyphenoxy)acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(6-methoxybenzothiazol-2-yl)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-{2-[(4-fluorophenyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-methoxyphenoxy)-2-{2-[(4-methoxyphenyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-{2-[(4-methoxyphenyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-{3-[(4-fluorophenyl) sulfonyl]phenyl}-2-(4-methoxyphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(3-chlorophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(3-methylphenoxy)acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-phenoxyacetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyano-3-fluorophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(2-methoxyethoxy)acetamide, N-(2H-1,3-dioxolano[4,5-g]benzothiazol-7-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, N-(2H-1,3-dioxolano[4,5-g]benzothiazol-7-yl)-2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(5-methoxybenzothiazol-2-yl)acetamide, N-(4,7-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, N-(2H-1,3-dioxoleno[4,5-f]benzothiazol-6-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, N-(4,7-dimethoxybenzothiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl]-2-(4-methoxyphenoxy)acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-[6-(4-methylpiperazinyl)benzothiazol-2-yl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-{2-[benzylsulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-[2-(ethylsulfonyl)phenyl]acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-{3-[(4-fluorophenyl)sulfonyl]phenyl}acetamide, N-(5,6-dimethoxybenzothiazol-2-yl)-2-(4-cyanophenoxy)-2-{3-[benzylsulfonyl]phenyl}acetamide, N-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-[4-(3-methoxyphenyl)(1,3-thiazol-2-yl)]acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(4-phenyl(1,3-thiazol-2-yl))acetamide, methyl 2-(2-{2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]acetylamino}-1,3-thiazol-4-yl)acetate, 4-{1-[4-(ethylsulfonyl)phenyl]-2-(4-hydroxypiperidyl)-2-oxoethoxy}benzenecarbonitrile, 4-{1-[4-(ethylsulfonyl)phenyl]-2-oxo-2-(4-oxopiperidyl)ethoxy}benzenecarbonitrile, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(4-hydroxycyclohexyl)acetamide, 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(3-methoxypropyl)acetamide and 2-(4-cyanophenoxy)-2-[4-(ethylsulfonyl)phenyl]-N-(2-morpholin-4-ylethyl)acetamide.
A compound selected from the group consisting of:
- N-[1,3]Dioxolo[4′,5′:3,4]benzo[2,1-d]thiazol-7-yl-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(7,8-Dihydro-6,9-dioxa-3-thia-1-aza-cyclopenta[a]naphthalen-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5-Dimethylamino-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5-Diethylamino-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Ethanesulfonyl-phenyl)-N-[6-(4-methyl-piperazin-1-yl)-benzothiazol-2-yl]-acetamide, N-(5,6-Dimethoxy-1H-benzoimidazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-dimethoxy-benzooxazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyclopropylmethanesulfonyl-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[4-(propane-2-sulfonyl)-phenyl]-acetamide, 2-(4-Cyclopentanesulfonyl-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[4-(2-methoxy-ethanesulfonyl)-phenyl]-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(3-ethanesulfonyl-phenyl)-acetamide, 2-(3-Cyclopropylmethanesulfonyl-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[3-(propane-2-sulfonyl)-phenyl]-acetamide, 2-(3-Cyclopentanesulfonyl-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(3-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-dimethylsulfamoyl-phenyl)-acetamide, 2-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid, 3-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid, 3-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid methyl ester, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid methyl ester, 2-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N,N-dimethyl-benzamide, 3-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N,N-dimethyl-benzamide, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N,N-dimethyl-benzamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-propionamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-butyramide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-3-methyl-butyramide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-4-methoxy-butyramide, 3-Cyclopropyl-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-propionamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-3-phenyl-propionamide, 2-Cyclopentyl-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 1-(4-Ethanesulfonyl-phenyl)-cyclopropanecarboxylic acid (5,6-dimethoxy-benzothiazol-2-yl)-amide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-isopropoxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-methoxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-propoxy-acetamide, 2-Cyclopentyloxy-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-Cyclohexyloxy-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(3-methyl-butoxy)-acetamide, 2-Benzyloxy-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-isobutoxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(3-methyl-but-2-enyloxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yloxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(2-methoxy-ethoxy)-acetamide, 2-Cyclohexylmethoxy-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-ylmethoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(3-methoxy-propoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-phenethyloxy-acetamide, 2-(4-Cyano-benzyloxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide (SBI-0662457), 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-N-methyl-acetamide, 2-(3-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-2-trifluoromethyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(2-Chloro-4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(3-Chloro-4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-2-fluoro-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-3-fluoro-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-2-methyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-3-methyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(naphthalen-1-yloxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(naphthalen-2-yloxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-phenoxy-acetamide, 2-(4-Chloro-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(2-Chloro-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(3-Chloro-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Bromo-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-iodo-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-ethynyl-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(2-iodo-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-fluoro-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-trifluoromethyl-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-p-tolyloxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-o-tolyloxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-m-tolyloxy-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-ethyl-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-propyl-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-isopropyl-phenoxy)-acetamide, 2-(4-Butyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyclopentyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyclohexyl-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-trifluoromethoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(2-methoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(3-methoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-ethoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-propoxy-phenoxy)-acetamide, 2-(4-Butoxy-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Benzyloxy-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-nitro-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-dimethylamino-phenoxy)-2-(4-ethanesulfonyl-phenyl)-acetamide, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-(4-ethanesulfonyl-phenyl)-methoxy]-benzoic acid methyl ester, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-(4-ethanesulfonyl-phenyl)-methoxy]-benzoic acid, 4-[(5,6-Dimethoxy-benzothiazol-2-ylcarbamoyl)-(4-ethanesulfonyl-phenyl)-methoxy]-N,N-dimethyl-benzamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenylamino)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(3-methoxy-phenylamino)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(2-methoxy-phenylamino)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-p-tolylamino-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-m-tolylamino-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-o-tolylamino-acetamide, 2-(4-Cyano-phenylamino)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-isobutylamino-acetamide, 2-Cyclopentylamino-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-dimethylamino-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-piperidin-1-yl-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-morpholin-4-yl-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-phenylmethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(propane-2-sulfonyl)-phenyl]-acetamide, 2-[4-(Butane-1-sulfonyl)-phenyl]-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-cyclopropylmethanesulfonyl-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-methoxy-ethanesulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(2-phenylmethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(2-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[2-(propane-2-sulfonyl)-phenyl]-acetamide, 2-[2-(Butane-1-sulfonyl)-phenyl]-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[2-(4-fluoro-benzenesulfonyl)-phenyl]-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[2-(4-fluoro-benzenesulfonyl)-phenyl]-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[2-(4-methoxy-benzenesulfonyl)-phenyl]-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[2-(4-methoxy-benzenesulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(3-phenylmethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(3-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[3-(propane-2-sulfonyl)-phenyl]-acetamide, 2-[3-(Butane-1-sulfonyl)-phenyl]-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[3-(2-methyl-propane-2-sulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[3-(4-fluoro-benzenesulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[3-(4-methoxy-benzenesulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(4-fluoro-benzenesulfonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(4-methoxy-benzenesulfonyl)-phenyl]-acetamide, 2-[3-(4-Chloro-benzenesulfonyl)-phenyl]-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-[4-(4-Chloro-benzenesulfonyl)-phenyl]-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(4-trifluoromethyl-benzenesulfonyl)-phenyl]-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-(3-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide, N-(5,6-Dimethoxy-benzothiazol-2-yl)-2-[3-(4-fluoro-benzenesulfonyl)-phenyl]-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-dimethylsulfamoyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-methoxy-ethylsulfamoyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-dimethylamino-ethylsulfamoyl)-phenyl]-acetamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid methyl ester, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-benzoic acid, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N,N-dimethyl-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-methoxy-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-dimethylamino-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-morpholin-4-yl-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-piperidin-1-yl-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-pyrrolidin-1-yl-ethyl)-benzamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(piperazine-1-carbonyl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-trifluoromethyl-phenyl)-acetamide, 2-(3-Bromo-phenyl)-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-p-tolyl-acetamide, 2-(4-Chloro-phenyl)-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-fluoro-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-phenyl-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-nitro-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-methoxy-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-ethoxy-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-methoxy-ethoxy)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-isopropoxy-phenyl)-acetamide, 2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-acetamide, 2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-dimethylamino-ethoxy)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(1H-tetrazol-5-yl)-phenyl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-phenoxy-acetamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-benzoic acid methyl ester, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-benzoic acid, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-methoxy-ethyl)-benzamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-morpholin-4-yl-ethyl)-benzamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-hydroxy-ethyl)-benzamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-pyrrolidin-1-yl-ethyl)-benzamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-acetamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-dimethylamino-ethyl)-benzamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N-(2-piperidin-1-yl-ethyl)-benzamide, 4-[(4-Cyano-phenyl)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methoxy]-N,N-dimethyl-benzamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(piperazine-1-carbonyl)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-(4-hydroxy-phenoxy)-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-methoxy-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-dimethylamino-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-hydroxy-ethoxy)-phenoxy]-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(1H-tetrazol-5-yl)-phenoxy]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(5-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5-diethylamino-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Ethanesulfonyl-phenyl)-N-(6-methoxy-benzothiazol-2-yl)-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-(4-methyl-piperazin-1-yl)-benzothiazol-2-yl]-acetamide, 2-(4-Ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-N-[6-(4-methyl-piperazin-1-yl)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-morpholin-4-yl-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(4,7-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(4,7-Dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-N-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]thiazol-6-yl-2-(4-ethanesulfonyl-phenyl)-acetamide, N-[1,3]Dioxolo[4′,5′:4,5]benzo[1,2-d]thiazol-6-yl-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide, 2-(4-cyano-phenoxy)-N-(6,7-dihydro-5,8-dioxa-1-thia-3-aza-cyclopenta[b]naphthalen-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-[1,3]dioxolo[4′,5′:3,4]benzo[2,1-d]thiazol-7-yl-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(7,8-dihydro-6,9-dioxa-3-thia-1-aza-cyclopenta[a]naphthalen-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-(2-methoxy-ethoxy)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-(2-morpholin-4-yl-ethoxy)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-(2-hydroxy-ethoxy)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-{6-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzothiazol-2-yl}-acetamide, 2-(4-Cyano-phenoxy)-N-(7,8-dihydro-6,9-dioxa-1-thia-3-aza-cyclopenta[a]naphthalen-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(7,8-Dihydro-6,9-dioxa-1-thia-3-aza-cyclopenta[a]naphthalen-2-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide, 2-(4-Cyano-phenoxy)-N-(1,3-dioxa-8-thia-6-aza-as-indacen-7-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-(1,3-Dioxa-8-thia-6-aza-as-indacen-7-yl)-2-(4-ethanesulfonyl-phenyl)-2-(4-methoxy-phenoxy)-acetamide 2-(4-Cyano-phenoxy)-N-(6,7-dimethoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(7-ethoxy-6-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(7-isopropoxy-6-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(7-methoxy-6-methyl-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-fluoro-7-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-methoxy-5-methyl-benzothiazol-2-yl)-acetamide, N-(5-Chloro-6-methoxy-benzothiazol-2-yl)-2-(4-cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(5-fluoro-6-methoxy-benzothiazol-2-yl)-acetamide, N-(6-Chloro-5-methoxy-benzothiazol-2-yl)-2-(4-cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(5-methoxy-6-methyl-benzothiazol-2-yl)-acetamide, N-(5-Benzyloxy-6-methoxy-benzothiazol-2-yl)-2-(4-cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(5-isopropoxy-6-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(5-ethoxy-6-methoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-methoxy-5-(2-methoxy-ethoxy)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[5-(2-hydroxy-ethoxy)-6-methoxy-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-N-(5-cyclopropylmethoxy-6-methoxy-benzothiazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-[5-(2-dimethylamino-ethoxy)-6-methoxy-benzothiazol-2-yl]-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[6-methoxy-5-(2-morpholin-4-yl-ethoxy)-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-[5-(2-fluoro-ethoxy)-6-methoxy-benzothiazol-2-yl]-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-methoxy-thiazolo[4,5-b]pyridin-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(6-methoxy-thiazolo[4,5-b]pyridin-2-yl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzooxazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, N-Benzooxazol-2-yl-2-(4-cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-acetamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzooxazol-2-ylcarbamoyl)-methyl]-N-(2-piperidin-1-yl-ethyl)-benzamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzooxazol-2-yl)-2-[4-(2-methoxy-ethoxy)-phenyl]-acetamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzooxazol-2-ylcarbamoyl)-methyl]-N,N-dimethyl-benzamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-benzooxazol-2-yl)-2-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-acetamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzooxazol-2-ylcarbamoyl)-methyl]-N-(2-morpholin-4-yl-ethyl)-benzamide, 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzooxazol-2-ylcarbamoyl)-methyl]-N-(2-methoxy-ethyl)-benzamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-1-methyl-1H-benzoimidazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-N-(5,6-dimethoxy-1H-indol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, 2-(4-Cyano-phenoxy)-2-(4-ethanesulfonyl-phenyl)-N-(1H-indol-2-yl)-acetamide, 2-(4-Chloro-phenyl)-2-(4-cyano-phenoxy)-N-(5,6-dimethoxy-benzothiazol-2-yl)-acetamide, 2-(4-Cyano-phenyl)-N-(5,6-dimethoxy-benzothiazol-2-yl)-2-[4-(2-dimethylamino-ethoxy)-phenoxy]-acetamide, N-(5,6-dimethoxy-benzooxazol-2-yl)-2-(4-ethanesulfonyl-phenyl)-acetamide, and 4-[(4-Cyano-phenoxy)-(5,6-dimethoxy-benzothiazol-2-ylcarbamoyl)-methyl]-N-(2-methoxy-ethyl)-benzamide.
Dependencies are inferred from the claim text.