Substituted pyrimidines for preventing or treating cancer and inflammatory diseases

A process for preparing a compound represented by Formula 1:

• wherein:
• R1 is chloro or methyl;
• R2 is hydrogen or chloro;
• R3 is hydrogen, fluoro, chloro, bromo, methyl, ethyl, isopropyl, pentyl, hexyl, octyl, methoxy, phenoxy, (4-nitrophenyl)sulfonyl, piperidin-4-yl, or piperazin-1-yl;
• R4 is hydrogen, chloro, methyl, trifluoromethyl, phenoxy, (4-nitrophenyl)sulfonyl, or piperidin-4-yl;
• or
• R3 and R4, together with the carbons to which they are attached, form a fused ring selected from the group consisting of:
• and
• n is 1 or 2;
• wherein the process comprises:
• (1) reacting a compound represented by Formula 2:
• wherein:
• R1 is chloro or methyl;
• with a compound represented by Formula 3:
• wherein:
• n is 1 or 2;
• to provide a compound represented by Formula 4:
• wherein:
• R1 is chloro or methyl;
• and
• n is 1 or 2;
• and
• (2) reacting the compound represented by Formula 4 above with a compound represented by Formula 5:
• wherein
• R2 is hydrogen or chloro;
• R3 is hydrogen, fluoro, chloro, bromo, methyl, ethyl, isopropyl, pentyl, hexyl, octyl, methoxy, phenoxy, (4-nitrophenyl)sulfonyl, piperidin-4-yl, or piperazin-1-yl;
• R4 is hydrogen, chloro, methyl, trifluoromethyl, phenoxy, (4-nitrophenyl)sulfonyl, or piperidin-4-yl;
• or
• R3 and R4, together with the carbons to which they are attached, form a fused ring selected from the group consisting of:
• in the presence of an acid, to provide the compound represented by Formula 1: