Anti-inflammatory 6-phenoxypyrimidine derivatives, process for their preparation and pharmaceutical composition containing them
AssigneeKorea Institute of Science and Technology
InventorsEun Joo Roh, Karam Mohamed Hasan Fara Ahmed, So Ra Paik, Woo Young Hur, Elkamhawy Ahmed
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Abstract
The present invention relates to a 6-phenoxypyrimidine derivative, a method for preparing the compound and a pharmaceutical composition containing the compound as an active ingredient. Because the 6-phenoxypyrimidine compound represented by Chemical Formula 1 according to the present invention has an activity of inhibiting the production of nitric oxide (NO) as an inflammation-related factor, it is useful in treating and preventing inflammatory diseases including immunological diseases.
Claims16
A compound selected from a group consisting of a 6-phenoxypyrimidine derivative represented by Chemical Formula 1 and a pharmaceutically acceptable salt thereof:
- wherein
- L is —C(O)NH—, —NHC(O)NH—, —CH═N— or —CH2—NH—;
- R1 is a halogen atom, a C1-C10 alkyl group, a C1-C10 alkoxy group or a C1-C10 haloalkyl group substituted with 1-10 halogen atom(s);
- R2 is a morpholine group or a C1-C10 alkoxy group;
- R3 is a halogen atom, a C1-C10 alkyl group, a C1-C10 alkoxy group or a C1-C10 haloalkyl or C1-C10 haloalkoxy group substituted with 1-13 halogen atom(s);
- and
- k, m and n are integers from 0 to 3 as the number of substituents.
Dependencies are inferred from the claim text.