Hsp70 modulators and methods for making and using the same

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• X is —N═;
• X1 is —C(R5)═;
• R1 is
• R1a is
• or C1-6 aliphatic optionally substituted with one or more groups independently selected from —OH, cyclopropyl, or 5-membered heteroaryl having 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur;
• each R1b is independently hydrogen or C1-4 alkyl, or two R1b groups are optionally taken together to form an oxo group;
• each of R1c and R1d is independently hydrogen or C1-4 alkyl;
• R2 is —O—CH2-Ring A, —NH—CH2-Ring A, or —O—CH2CH2-Ring A;
• Ring A is unsubstituted phenyl, unsubstituted furanyl,
• or pyridinyl optionally substituted with RA5;
• each of RA1 is independently halogen, —CN, —C(O)N(R)2, —N(R)2, —OR, —C(O)R, —N3, an optionally substituted 5- or 6-membered heterocyclyl or heteroaryl having one or two heteroatoms independently selected from nitrogen, oxygen, or sulfur, or C1-4 alkyl optionally substituted with one or more halogen;
• each R is independently hydrogen or C1-4 alkyl optionally substituted with one or more halogen;
• RA2 is —Cl, —Br, —I, —CN, —C(O)N(R)2, —N(R)2, —OR, —C(O)R, —N3, C1-4 alkyl optionally substituted with one or more halogen, or an optionally substituted 5- or 6-membered heterocyclyl or heteroaryl having one or two heteroatoms independently selected from nitrogen, oxygen or sulfur;
• n is 1 to 4;
• RA3 is —H or —F;
• RA4 is —F or —OR;
• RA5 is —OR or —N(R)2;
• R3 is —N(R3c)2;
• each R3a is independently hydrogen or C1 alkyl optionally substituted with one or more groups independently selected from halogen or 1-pyrrolidinyl;
• R3b is hydrogen or C1-4 alkyl optionally substituted with one or more groups independently selected from halogen, C1-4 alkyl, C1-4 haloalkyl, oxo, or —N(R)2;
• each R3c is independently hydrogen or C1-4 alkyl optionally substituted with one or more groups independently selected from halogen, C1-4 alkyl, C1-4 haloalkyl, oxo, or —N(R)2;
• R4 is R, halogen, or —N(R)2;
• and
• R5 is hydrogen, methyl or —N(R)2.