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US 10,647,682 B2Granted
Salts of 2,6-dimethylpyrimidone derivatives and uses thereof
AssigneeNorth & South Brother Pharmacy Investment Company Limited
InventorsRunfeng Lin, Liang Chen, Xiaojun Wang, Yingjun Zhang, Jiancun Zhang
Life of this patent
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Abstract
Provided are salts of 2,6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.
Claims14
A pharmaceutically acceptable acid addition salt of compound (I),
- wherein the salt is hydrochloride crystal-I, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 3.68±0.2°, 10.88±0.2°, 17.30±0.2°, 22.20±0.2°, and 26.67±0.2°;
- or
- the salt is hydrochloride crystal-II, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 6.12±0.2°, 8.83±0.2°, 15.56±0.2°, 19.69±0.2°, 25.24±0.2°, and 26.35±0.2°;
- or
- the salt is hydrochloride crystal-III, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 3.46±0.2°, 10.25±0.2°, 13.62±0.2°, and 17.26±0.2°;
- or
- the salt is sulfate crystal-I, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 3.35±0.2°, 6.61±0.2°, 16.50±0.2°, and 21.43±0.2°;
- or
- the salt is tosilate crystal-I, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 6.55±0.2°, 13.74±0.2°, 20.08±0.2°, 21.32±0.2°, 22.17±0.2°, and 22.99±0.2°;
- or
- the salt is maleate crystal-I, which is characterized by an X-ray powder diffraction pattern comprising peaks expressed as 2θ at 4.10±0.2°, 16.33±0.2°, and 20.45±0.2°.
8 more elements
Dependencies are inferred from the claim text.