Biaryl derivative and medicine containing same

A biaryl derivative represented by the formula (I) or a salt thereof:

• wherein
• ring A is a ring selected from the group consisting of
• wherein
• n is 1 or 2,
• R4 is
• halogen,
• cyano,
• hydroxyl,
• C1-C6 haloalkyl,
• heterocycloalkyl,
• heterocycloalkyloxy,
• a 5-membered ring heteroaryl group,
• C1-C6 haloalkoxy,
• C2-C6 alkenyl,
• C2-C6 alkenyl-C1-C6 alkoxy,
• C2-C6 alkynyl,
• C2-C6 alkynyl-C1-C6 alkoxy,
• C1-C6 alkylthio,
• —NRdRe, wherein Rd and Re are each independently hydrogen or C1-C6 alkyl,
• nitro,
• formyl,
• C1-C6 alkylcarbonyl,
• C1-C6 alkoxycarbonyl,
• C1-C6 alkylcarbonyloxy group, or
• an optionally substituted group selected from the group consisting of C1-C6 alkyl, C3-C7 cycloalkyl, and C1-C6 alkoxy,
• R5a, R5b, and R5c are each independently
• hydrogen,
• halogen,
• cyano,
• C1-C6 alkyl,
• C1-C6 alkoxy,
• C1-C6 haloalkyl,
• C1-C6 haloalkoxy,
• C3-C7 cycloalkyl,
• C1-C6 alkylcarbonyl, or
• C1-C6 alkoxycarbonyl,
• X4 is NRf, O, or S, wherein Rf is hydrogen or C1-C6 alkyl, and
• R6a and R6b are each independently
• hydrogen,
• halogen,
• C1-C6 haloalkyl,
• C1-C6 haloalkoxy, or
• an optionally substituted group selected from the group consisting of
• C1-C6 alkyl,
• C3-C7 cycloalkyl,
• C1-C6 alkoxy, and
• C1-C6 alkylthio,
• Q is O,
• X1, X2 and X3 are each CR1,
• Y is CH,
• Z is CR2b,
• each R1 independently is
• hydrogen,
• halogen,
• C1-C6 alkyl,
• C1-C6 haloalkyl,
• C1-C6 alkoxy or
• C1-C6 haloalkoxy,
• R2a and R2b are each independently
• hydrogen,
• halogen,
• hydroxyl,
• cyano,
• formyl,
• a pentafluorosulfanyl group,
• —NRaRb, wherein Ra and Rb are each independently hydrogen or an optionally substituted C1-C6 alkyl group, provided that Ra and Rb are not both hydrogen,
• an optionally substituted group selected from the group consisting of
• C1-C6 alkyl,
• C1-C6 haloalkyl,
• C1-C6 alkoxy,
• C1-C6 haloalkoxy,
• C1-C4 alkoxy-C1-C4 alkyl,
• C1-C4 alkoxy-C1-C4 haloalkyl,
• C1-C6 alkylcarbonyl,
• C1-C6 alkoxycarbonyl,
• C1-C6 alkylcarbonyloxy,
• C3-C7 cycloalkyl,
• heterocycloalkyl,
• heterocycloalkyloxy,
• C2-C6 alkenyl,
• C2-C6 alkenyloxy,
• C2-C6 alkenyl-C1-C6 alkyl,
• C2-C6 alkenyl-C1-C6 alkoxy,
• C2-C6 alkenyloxy-C1-C4 alkyl,
• C2-C6 alkenyloxy-C1-C4 alkoxy,
• C2-C6 alkenyloxy-C1-C4 haloalkyl,
• C2-C6 alkenyloxy-C1-C4 haloalkoxy,
• C2-C6 alkynyl,
• C2-C6 alkynyloxy,
• C2-C6 alkynyl-C1-C6 alkyl,
• C2-C6 alkynyl-C1-C6 alkoxy,
• C2-C6 alkynyloxy-C1-C4 alkyl,
• C2-C6 alkynyloxy-C1-C4 alkoxy,
• C2-C6 alkynyloxy-C1-C4 haloalkyl,
• C2-C6 alkynyloxy-C1-C4 haloalkoxy,
• C1-C6 alkylthio, and
• C1-C6 haloalkylthio,
• or
• a group of formula (I-A)
• wherein
• L is a single bond, —(CH2)p—, —O(CH2)p—, —(CH2)pO—, —(CH2)pO(CH2)q—, —NRc(CH2)p—, —(CH2)pNRc or —(CH2)pNRc(CH2)q—, wherein one or more hydrogen atoms of (CH2)p and (CH2)q are each optionally substituted by halogen, C1-C4 alkyl, or C3-C7 cycloalkyl,
• p is 1, 2 or 3,
• q is 1, 2 or 3,
• Rc is hydrogen or C1-C6 alkyl, and
• ring B is an optionally substituted carbocycle, or an optionally substituted heterocycle, or
• R2a and R2b can be joined to form —(CH2)r— that is optionally substituted by halogen, hydroxyl, or oxo and r is 3, 4, 5, or 6, and
• R3 is
• hydrogen,
• halogen,
• C1-C6 haloalkyl,
• C1-C6 haloalkoxy, or
• an optionally substituted group selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and aralkyl.