Acetophenone compound, preparation method thereof, and application thereof in fatty liver prevention and treatment

A compound of Formula I or a pharmaceutically acceptable salt thereof,

• wherein,
• X is selected from oxygen;
• Z is selected from imino;
• Q is selected from methylene (—CH2—);
• R1 is selected from
• R2 is selected from
• R3 is selected from H;
• halogen;
• hydroxyl;
• amino;
• nitro;
• cyano;
• C1-C10 alkyl;
• C1-C10 alkoxyl;
• or C3-C10 cycloalkyl,
• n is an integer selected from 0 to 1;
• p is 0;
• wherein,
• R4 is selected from H or C1-C10 alkyl;
• R5 or R6 is independently selected from the optionally substituted groups of:
• phenyl;
• 5- to 6-membered monocyclic heteroaryl having 1 to 4 heteroatom(s) independently selected from nitrogen;
• or
• wherein R7 or R8 is independently selected from H or from substituted or unsubstituted C1-C10 alkyl;
• R9 is selected from phenyl, monosubstituted phenyl or multi-substituted phenyl, wherein the substituent for phenyl is selected from halogen;
• hydroxyl;
• C1-C10 alkyl;
• or C1-C10 alkoxyl,
• m is an integer selected from 0 to 8;
• said “substituted” refers to substituents chosen from halogen;
• C1-C10 alkyl;
• C3-C10 cycloalkyl;
• C1-C10 alkyl substituted with C5-C10 aryl;
• C5-C10 aryl;
• 3- to 10-membered heterocyclic group having 1 to 3 heteroatom(s) independently selected from nitrogen or oxygen;
• or 5- to 10-membered heteroaryl having 1 to 4 heteroatom(s) independently selected from nitrogen or oxygen.