Heterodimers of glutamic acid

A method of making a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, comprising the use of an intermediate having the formula:
• wherein:
• R is a C6-C12 substituted or unsubstituted aryl, a C3-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl, or NR′R′;
• each R′ is independently hydrogen, a C6-C12 substituted or unsubstituted aryl, a C3-C12 substituted or unsubstituted heteroaryl, or a C1-C6 substituted or unsubstituted alkyl;
• when substituted, aryl, heteroaryl, and alkyl are substituted with halogen, C3-C12 heteroaryl, or COOZ;
• each Z is independently hydrogen or C1-C4 alkyl;
• Q is NR′;
• Y is C(O), O, NR′, S(O)2, C(O)2, or (CH2)p;
• m is 4;
• n is 0;
• p is 0, 1, 2, 3, 4, 5 or 6;
• and
• further wherein:
• (i) at least one of R or R′ is a C6-C12 aryl or C3-C12 heteroaryl substituted with a halogen, or
• (ii) at least one of R or R′ is a C3-C12 heteroaryl.

A method of making a compound of the following structure:

• or a pharmaceutically acceptable salt thereof, comprising the use of an intermediate having the formula:
• wherein:
• X is selected from hydrogen and halogen;
• and
• each Z is independently hydrogen or C1-C4 alkyl.