Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
AssigneesThe J. David Gladstone Institutes, The Regents of the University of California, Ithaca College
InventorsEric Verdin, Scott Michael Ulrich, John C. Newman
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Abstract
Aspects of the present disclosure include fatty acid β-hydroxyester compounds (e.g., fatty acid esters of β-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid β-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.
Claims30
A compound of the formula:
- and salts, solvates or hydrates thereof, wherein:
- R1 is C(1-6) alkyl or substituted alkyl;
- and
- R2 and R3 are independently unsubstituted or substituted C(4-30) alkyl.
Dependencies are inferred from the claim text.