Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal
AssigneesKyowa Hakko Bio Co., Ltd., Otsuka Pharmaceutical Factory, Inc.
InventorsTomoya Yokoi, Hiroshi Nagano, Takayuki Shimizu
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Abstract
The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.
Claims23
A crystal of a monovalent cation salt of 3-hydroxyisovaleric acid, wherein the monovalent cation salt is a sodium salt having a powder X-ray diffraction with crystal peaks at diffraction angles (2θ) of 8.4±0.2°, 6.6±0.2°, 19.7±0.2°, 13.3±0.2°, and 29.4±0.2°;
- the monovalent cation salt is a sodium salt having a powder X-ray diffraction with crystal peaks at diffraction angles (2θ) of 6.7±0.2°, 13.3±0.2°, and 20.0±0.2°;
- the monovalent cation salt is a potassium salt having a powder X-ray diffraction with crystal peaks at diffraction angles (2θ) of 9.0±0.2°, 27.1±0.2°, 23.8±0.2°, 16.1±0.2°, and 22.9±0.2°;
- or
- the monovalent cation salt is an ammonium salt having a powder X-ray diffraction with crystal peaks at diffraction angles (2θ) of 19.9±0.2°, 21.1±0.2°, 29.9±0.2°, 17.3±0.2°, and 18.0±0.2°.
Dependencies are inferred from the claim text.