Back to results
US 10,646,899 B2Granted
Cell sorter
AssigneeKabushiki Kaisha Toshiba
InventorsKaita Imai, Shouhei Kousai, Yosuke Akimoto, Michihiko Nishigaki, Yutaka Onozuka, Miyu Nagai
Life of this patent
Estimating the term…
Abstract
According to one embodiment, a cell sorter includes a flow channel which supplies a sample liquid containing particles, a plurality of branch channels connected to the flow channel, an image sensor which has a pixel region covering the flow channel and the branch channels, a determination unit which determines the characteristics of the particles in the sample liquid from a measurement signal of the pixel region, and a separation unit guides the particles in the sample liquid to any of the branch channels based on the determination result of the determination unit.
Claims19
A cell sorter, comprising:
- a substrate;
- a flow channel which supplies a sample liquid containing particles from one end side;
- a plurality of branch channels which are connected to the other end side of the flow channel;
- an image sensor which is provided in a surface region of the substrate, which is located beneath bottoms of the flow channel and the branch channels, and which has a pixel region covering the flow channel and the branch channels;
- a determination unit which determines the characteristics of the particles in the sample liquid from a measurement signal of the pixel region of the portion of the flow channel of the image sensor;
- and
- a separation unit which is provided adjacently to the connection of the flow channel and the branch channels and guides the particles in the sample liquid to any of the branch channels based on the determination result of the determination unit,
- wherein the pixel region further covers the separation unit.
5 more elements
A cell sorter, comprising:
- a substrate;
- a plurality of cell sorter elements arranged in series, the cell sorter elements each comprising:
- a flow channel which supplies a sample liquid containing particles from one end side;
- a plurality of branch channels whose one end is connected to the other end side of the flow channel;
- an image sensor which is provided in a surface region of the substrate, which is located beneath bottoms of the flow channel and the branch channels, and which has a pixel region covering the flow channel and the branch channels;
- a determination unit which determines the characteristics of the particles in the sample liquid from a measurement signal of the pixel region of the portion of the flow channel of the image sensor;
- and
- a separation unit which is provided adjacently to the connection of the flow channel and the branch channels and guides the particles in the sample liquid in the flow channel to any of the branch channels based on the determination result of the determination unit;
- wherein,
- one end of the flow channel of the cell sorter element at the downstream side is connected to the other end of one of the branch channels of the cell sorter element at the upstream side,
- the determination unit of each of the cell sorter elements determines different characteristic of particles, and
- wherein the pixel region further covers the separation unit.
9 more elements
A cell sorter, comprising:
- a substrate
- a flow channel section in which a cell sorter element having a first flow channel for supplying a sample liquid containing particles from one end side and a plurality of branch channels whose one end is connected to the other end side of the first flow channel is multi-stage arranged;
- an image sensor which is provided in a surface region of the substrate, which is located beneath a bottom of the flow channel section, and which has a pixel region which covers the whole of the first flow channel and the branch channels or a pixel region which covers the flow channel section, for the cell sorter element;
- a determination unit which determines the characteristics of particles in the sample liquid from a measurement signal of the pixel region of the portion of the first flow channel of the image sensor, for the cell sorter element;
- and
- a separation unit which is provided adjacently to the connection of the first flow channel and the branch channels and guides particles in the sample liquid in the first flow channel to any of the branch channels based on the determination result of the determination unit, for the cell sorter element,
- wherein the pixel region further covers the separation unit.
4 more elements
Dependencies are inferred from the claim text.