Material for blood purification
AssigneeToray Industries, Inc.
InventorsShungo Kanda, Hiroshi Takahashi, Naotoshi Tomita
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Abstract
An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.
Claims24
A material for blood purification, the material comprising a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate,
- wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material;
- wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material;
- wherein the ligand having the structure represented by Formula below is bound to the substrate:
- wherein l is an integer of 1 to 5, m is an integer of 1 to 5, X is a group having one or more amines as a partial structure;
- A is a linker;
- B is a hydrogen atom or halogen atom;
- C is a hydrogen atom or halogen atom;
- and the wavy line represents a position at which the ligand is bound to the substrate;
- and wherein the content of the phenyl group is more than 0 mmol and not more than 7.0 mmol per 1 g dry weight of the water-insoluble material.
A method for blood purification comprising:
- contacting a quantify of blood with a material to purify the blood, said material comprising a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate,
- wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material;
- wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material;
- wherein the ligand having the structure represented by Formula below is bound to the substrate:
- wherein l is an integer of 1 to 5, m is an integer of 1 to 5, X is a group having one or more amines as a partial structure;
- A is a linker;
- B is a hydrogen atom or halogen atom;
- C is a hydrogen atom or halogen atom;
- and the wavy line represents a position at which the ligand is bound to the substrate;
- and wherein the content of the phenyl group is more than 0 mmol and not more than 7.0 mmol per 1 g dry weight of the water-insoluble material.
Dependencies are inferred from the claim text.