Intravesical drug delivery methods and devices

A method for administration of a drug into a patient's bladder, comprising:

• inserting a distal end of a lumen device through a patient's urethra and into the patient's bladder, wherein an opposing proximal end of the lumen device remains outside of the patient;
• driving an elastically deformed drug delivery device out of a lumen in the distal end of the lumen device and into the bladder and out of the lumen, whereupon exiting the lumen, the drug delivery device immediately returns to an undeformed coiled shape for retention in the bladder, wherein the drug delivery device comprises a non-resorbable elastomeric tube, which has a central channel, and a drug formulation disposed within the central channel, the drug formulation comprising the drug;
• removing the lumen device from the patient's urethra;
• and
• releasing the drug from the drug delivery device into the patient's bladder,
• wherein the drug delivery device comprises an elastic wire retention frame which in the undeformed coiled shape has exactly two smaller arches sharing a single common larger arch, wherein the three arches resist compression and prevent collapse of the drug delivery device and thereby impede voiding of the drug delivery device from the bladder.

A method for administration of a drug into a patient's bladder, comprising:

• providing a lumen device, which has a distal end, an opposing proximal end, and an open lumen extending therebetween;
• inserting the distal end of the lumen device into the bladder of a patient in need of treatment, where the proximal end of the lumen device remains outside of the patient;
• deforming an implantable medical device for controlled drug delivery and passing it into the proximal end of the lumen of the lumen device, wherein the implantable medical device comprises (i) at least one drug reservoir component comprising a drug;
• and (ii) a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame;
• driving the deformed device through the lumen and out of the lumen, whereupon the implantable medical device returns to its undeformed shape for retention in the bladder;
• removing the lumen device from the patient;
• and
• releasing the drug from the implantable medical device,
• wherein the undeformed shape for retention in the bladder has exactly two smaller arches sharing a single common larger arch.