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US 10,646,623 B2Granted
Implantable medical device
AssigneeDepuy International Limited
InventorsYufu Li, Deborah Schachter, Raymond S. Shissias, Sandra Wechsler
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Abstract
An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.
Claims19
An implantable medical device comprising:
- an orthopedic device substrate having a surface;
- a coating on at least a portion of the surface of the substrate, the coating having a thickness of about less than 10 μm, the coating comprising a water soluble antibiotic drug;
- and,
- a protective layer disposed over the coating, the protective layer comprising a biodegradable polymer that is polylactic acid or a lactic acid copolymer and having a weight average molecular weight of not more than 40,000 g/mol;
- wherein the device is configured to provide an initial burst release of at least 60% of the antibiotic drug within 10 hours of implantation and at least 90% of the antibiotic drug within 1 week;
- wherein the device is configured to contact bone;
- and,
- wherein the device is configured to control infection at an orthopedic surgical site.
5 more elements
Dependencies are inferred from the claim text.