Bone graft

A bone graft comprising at least two bone matrix scaffolds, each of the bone matrix scaffolds having at least one sheet material that has been exposed to microgravity over its development,

• wherein each of said at least one sheet material comprises a surface pattern that enhances osteo-conductivity and supports osteo-inductivity, wherein the surface pattern is a bone-formation-enhancing repeatable geometric 3-dimensional pattern duplicating or replicating cancellous morphology of under-modelled pre-cancellous bone mimicking a marine or sea mammal bone structure, wherein the repeatable geometric 3-dimensional pattern is repeatably placed on portions of exposed surfaces of the sheet material to create a substantially continuous network having voids formed as a trabecular structure which enhances bone formation,
• wherein the at least two bone matrix scaffolds are parallel to each other and being connected by a series of collagen fibers arranged in a crisscross pattern between adjacent bone matrix scaffolds, the crisscross pattern similar to spokes pattern on a bicycle tire,
• wherein the bone graft experience enhanced tensile loading when exposed to normal gravitational forces,
• wherein said surface pattern is introduced by etching and/or embossing the exposed surfaces of the sheet material,
• wherein the bone graft further comprises osseous material and/or chondral material.