Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method

A method for producing a bone-regeneration material comprising biodegradable fiber using an electrospinning process, comprising:

• providing a PLGA resin to a kneader and heating the PLGA resin while rotating a blade of the kneader to soften the PLGA resin to a viscosity of 103.2 to 103.6 Pa·s;
• mixing powder of calcium phosphate fine particles with the softened PLGA resin by providing the powder into the kneader while rotating the blade;
• rotating the blade of the kneader with continuous force under the heating to knead the mixture so that thermal and mechanical energy is applied to the mixture to produce a composite of the PLGA resin and the calcium phosphate fine particles dispersed in the PLGA resin;
• cooling and solidifying the composite;
• dissolving the composite with a solvent, and stirring the dissolved composite for a predetermined time to prepare a spinning solution in which the PLGA resin is completely dissolved by the solvent and the calcium phosphate fine particles are substantially uniformly dispersed in the solvent;
• and
• charging the spinning solution into a syringe of an electrospinning apparatus and applying voltage to produce a biodegradable fiber in which the calcium phosphate fine particles are substantially uniformly dispersed.