Dissolvable hydrogel compositions for wound management and methods of use
AssigneeTrustees of Boston University
InventorsMark W. Grinstaff, Cynthia Ghobril, Michel Christophe Wathier, Marlena Dagmara Konieczynska
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Abstract
The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
Claims20
A dissolvable hydrogel composition comprising:
- an adhesive hydrogel layer comprising a first water-soluble linear, branched and/or dendritic crosslinkable polymer and a second water-soluble linear, branched and/or dendritic crosslinkable polymer held together by covalent bonds formed between the first crosslinkable polymer and the second crosslinkable polymer, wherein the second crosslinkable polymer comprises at least two thioester linkages within its backbone.
Dependencies are inferred from the claim text.