Wound spray
AssigneeMölnlycke Health Care AB
InventorsMichael Sander, Harald Potzschke
Life of this patent
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Abstract
The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.
Claims15
A method for the external treatment of an open wound surface, comprising spraying on the open wound surface an aqueous composition comprising:
- (a) an oxygen carrier, wherein al least 40% of oxygen binding sites of said oxygen carrier are charged by a non-O2 ligand, such that the oxygen carrier is sprayed on the open wound surface with the oxygen carrier in its non-oxidized state in the spray and provides availability of oxygen to the open wound surface in the presence of oxygen partial pressure in air as opposed to a pressurized chamber of pure oxygen, and
- (b) at least one further ingredient selected from the group consisting of electrolyte(s), preservative(s), stabilizer(s), anti-flocculant(s), anticoagulant(s), pH buffering agent(s), solvent(s), antioxidant(s), film-forming agent(s) and crosslinking agent(s), wherein the oxygen carrier is hemoglobin and the non-O2 ligand is carbon monoxide (CO).
A method for the external treatment of an open wound surface, comprising spraying from an aerosol on the open wound surface an aqueous composition comprising:
- (a) a hemoglobin oxygen carrier, wherein at least 40% of oxygen binding sites of the hemoglobin oxygen carrier are charged by carbon monoxide to render the hemoglobin oxygen carrier in a non-oxidized/non-activated status, such that the oxygen carrier is sprayed on the open wound surface with the oxygen carrier in its non-oxidized state in the spray and provides availability of oxygen to the open wound surface in the presence of oxygen partial pressure in air as opposed to a pressurized chamber of pure oxygen, and
- (b) at least one further ingredient selected from the group consisting of electrolyte(s), preservative(s), stabilizer(s), anti-flocculant(s), anticoagulant(s), pH buffering agent(s), solvent(s), antioxidant(s), film-forming agent(s) and crosslinking agent(s).
Dependencies are inferred from the claim text.