Near-infrared dye-bound transferrin, and contrast agent for photoacoustic imaging, including the near-infrared dye-bound transferrin
AssigneeCanon Kabushiki Kaisha
InventorsFumio Yamauchi, Kengo Kanazaki, Satoshi Ogawa
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Abstract
A novel near-infrared dye-bound transferrin exhibiting a high absorption coefficient in the near-infrared wavelength region, a high tumor accumulation property, a high tumor/blood ratio and a high imaging contrast, and a contrast agent for photoacoustic imaging, including the same are provided. A compound is provided in which transferrin and an organic dye having a specified structure that absorbs light in the near-infrared wavelength region are covalently bound.
Claims6
A contrast agent comprising a compound represented by formula (I-1):
- TF−(D)n (I-1),
- wherein, in the formula (I-1), TF represents transferrin, n is 4.8 to 7.0, and D represents formula (d5) or formula (d6):
- wherein, in the formulae (d5) and (d6), * represents a binding bond bound to the transferrin, and
- wherein, in the formula (d6), Y− represents a halogen ion or an organic acid ion.
A contrast agent comprising a compound represented by formula (I-1):
- TF−(D)n (I-1),
- wherein, in the formula (I-1), TF represents transferrin, D represents a near-infrared dye of formula (d5), and n is 4.8 to 7.0:
- wherein, in the formula (d5), * represents a binding bond bound to an amino group in the transferrin.
Dependencies are inferred from the claim text.