Thyroid stimulating hormone receptor peptides and uses thereof
AssigneeApitope International NV
InventorsLotta Jansson, Keith Martin, David Wraith, Andrea Jahraus, Kathleen Vrolix
Life of this patent
Estimating the term…
Abstract
The present invention provides a composition which comprises the following Thyroid Stimulating Hormone Receptor (TSHR) peptides: (i) all or part of the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO: 1), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:1; and (ii) all or part of the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO: 2), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:2. The present invention also relates to the use of such a composition for the prevention or suppression of activating autoantibody formation in Graves' disease.
Claims12
A composition which comprises the following peptides:
- (i) a peptide comprising the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO:
- 1), or a sequence having at least 85% sequence identity to SEQ ID NO:
- 1;
- and
- (ii) a peptide comprising the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO:
- 2), or a sequence having at least 85% sequence identity to SEQ ID NO:
- 2.
A kit which comprises the following peptides:
- (i) a peptide comprising the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO:
- 1), or a sequence having at least 85% sequence identity to SEQ ID NO:1;
- and
- (ii) a peptide comprising the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO:
- 2), or a sequence having at least 85% sequence identity to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.