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US 10,646,576 B2Granted
Immunostimulating-toxic RNA in alkaline earth metal formulation
AssigneespRNA GmbH
InventorSteve Pascolo
Life of this patent
Estimating the term…
Abstract
A composition including an immunostimulating RNA molecule in a dication containing solution wherein the RNA includes a chemical modification which is toxic to cancer or tumor cells. Pharmaceutical compositions incorporate the immunostimulating RNA with tumor cytotoxicity. Methods for treating cancer and tumors use the solution of the immunostimulating RNA with tumor cytotoxicity.
Claims26
A composition comprising:
- an RNA molecule having an immunostimulating activity in a dication containing solution, wherein the RNA molecule has a chemical modification which is tumor cytotoxic chemical moiety being a cyanide group or a tumor toxin or an inhibitor of tyrosine kinase or an inhibitor of mutated oncogene.
A composition comprising:
- an RNA molecule having an immunostimulating activity in a dication containing solution, wherein the RNA molecule has a chemical modification which is toxic to tumor cells being one or more cytotoxic nucleotide analogue(s) having a chemical modification selected from the group consisting of 5-fluoro-uridine, 6-mercaptopurine, pentostatin and 2-chloro-adenine at a base and/or sugar moiety of the RNA molecule and the RNA molecule has one or more sequences selected from the group consisting of:
- (SEQ ID NO:
- 1)
- A5A55C55G5A5GGGGGG
- (SEQ ID NO:
- 2)
- GGGGGGA55C55G5A5A5
- (SEQ ID NO:
- 3)
- AG5G55A5C55G5A5GGGGGG
- (SEQ ID NO:
- 4)
- A5A55C55G5A5GGGGGGGGGGGG
- (SEQ ID NO:
- 5)
- GGGGGGA5A55C55G5A5GGGGGG
- (SEQ ID NO:
- 6)
- A5A55555G5A5GGGGGG
- (SEQ ID NO:
- 7)
- GGGGGGA5A55C55G5A5GGGGGG
- wherein the above sequences are written, from left to right, in 5′ to 3′ direction, and “5” denotes a 5-fluoro-uridine nucleotide.
20 more elements
A composition comprising:
- an RNA molecule having an immunostimulating activity in a dication containing solution, wherein the RNA molecule has a chemical modification which is toxic to tumor cells being one or more cytotoxic nucleotide analogue(s) having a chemical modification selected from the group consisting of cytarabine, fludarabine and gemcitabine at a base and/or sugar moiety of the RNA molecule.
Dependencies are inferred from the claim text.