Back to results
US 10,646,569 B2Granted
High concentration protein formulations with reduced viscosity
AssigneeBhami's Research Laboratory, Pvt. Ltd.
InventorBhami Shenoy
Life of this patent
Estimating the term…
Abstract
The present disclosure, among other things, provides low-viscosity, high concentration therapeutic protein agent formulations.
Claims8
An antibody agent formulation comprising:
- (i) one or more antibody agents at a concentration between about 10 mg/mL and about 300 mg/mL;
- and
- (ii) a viscosity-reducing agent that comprises a combination of nicotinic acid (acid form) and tryptophan, present at a concentration between about 5 mM and about 100 mM each, wherein:
- the formulation has a viscosity between about 1 cP and about 100 cP when measured at 25° C., using a cone and plate viscometer.
1 more element
Dependencies are inferred from the claim text.