Compositions and uses
AssigneeGlaxosmithkline Biologicals SA
InventorsDavid Burkhart, Michael Cochran, Christopher W Cluff, Daniel Larocque, Helene G Bazin-Lee, Julien St Jean
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Abstract
The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.
Claims16
An immunogenic composition comprising an antigen-adjuvant conjugate, said conjugate comprises an oxoadenine compound covalently linked to an antigen, wherein the oxoadenine compound has a structure selected from the group of
The immunogenic composition of claim/wherein the crosslinking agent increases the aqueous solubility of the oxoadenine compound compared to the solubility in the absence of the crosslinking agent.
Dependencies are inferred from the claim text.