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US 10,646,555 B2Granted
Compositions and methods relating to argininosuccinate synthetase
AssigneeBioRegency, Inc.
InventorsStanislav I. Svetlov, Victor Prima, Alvin Wang, Gabriel Molina, Kevin Ka-wang Wang
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Abstract
Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby argininosuccinate synthetase or PEGylated argininosuccinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.
Claims12
A process of treating bacterial endotoxin exposure in a subject, comprising:
- obtaining a sample from the subject exposed to a bacterial endotoxin circulating in blood of the subject prior to said obtaining;
- detecting whether argininosuccinate synthetase is present in the biological sample by contacting the biological sample with an anti-argininosuccinate synthetase antibody and detecting binding between the argininosuccinate synthetase and the antibody;
- determining that levels and activity of the argininosuccinate synthetase in said sample from the subject are elevated over a normal level and normal activity of the arginosuccinate synthetase absent exposure to the bacterial endotoxin;
- and
- administering a therapeutically effective amount of additional argininosuccinate synthetase to the subject when the argininosuccinate synthetase in the biological sample is detected over the normal level and the normal activity.
2 more elements
Dependencies are inferred from the claim text.