Pharmaceutical compositions and methods
AssigneeTyme, Inc.
InventorSteven Hoffman
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof a p450 3A4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. Also provided are methods of reducing cell proliferation in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
Claims31
A method of treating ovarian cancer in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor;
- a melanin promoter;
- a p450 3A4 promoter;
- and a leucine aminopeptidase inhibitor to the subject in need thereof, wherein:
- the melanin promoter is methoxsalen or melanotan II;
- the p450 3A4 promoter is 5, 5-diphenylhydantoin, valproic acid, or carbamazepine;
- and
- the leucine aminopeptidase inhibitor is N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl]-L-leucine or rapamycin.
Dependencies are inferred from the claim text.