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US 10,646,545 B2Granted
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
AssigneeHeat Biologics, Inc.
InventorsTaylor Schreiber, George Fromm, Suresh De Silva
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Abstract
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
Claims23
A heterologous chimeric protein comprising:
- (a) a first domain comprising a portion of T-cell immunoreceptor with Ig and ITIM domains (TIGIT) that is capable of binding a TIGIT ligand,
- (b) a second domain comprising a portion of OX-40 ligand (OX40L) that is capable of binding an OX-40L receptor, and
- (c) a linker linking the first domain and the second domain and comprising a hinge-CH2-CH3 Fc domain.
A recombinant fusion protein comprising:
- (a) a first domain comprising a portion of T-cell immunoreceptor with Ig and ITIM domains (TIGIT) that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 35 and is capable of binding a TIGIT ligand,
- (b) a second domain comprising a portion of OX-40 ligand (OX40L) that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 56 and is capable of binding an OX-40L receptor, and
- (c) a linker linking the first domain and the second domain and comprising a hinge-CH2-CH3 Fc domain.
2 more elements
Dependencies are inferred from the claim text.