Peptide inhibitors of twist
AssigneeCity of Hope
InventorCarlotta A. Glackin
Life of this patent
Estimating the term…
Abstract
The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Claims20
A method of treating cancer or inhibiting metastasis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a TWIST inhibitor, wherein the TWIST inhibitor comprises a TWIST peptide, wherein the TWIST peptide comprises an amino acid sequence comprising at least 80% sequence identity to SEQ ID NO:
- 1.
A method of treating cancer or inhibiting metastasis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a TWIST peptide, wherein the TWIST peptide comprises at least 10 amino acids in length and comprises least 80% sequence identity to TWIST1 or TWIST2, and wherein said peptide:
- (a) retains the ability to bind the NF-κB subunit RELA;
- (b) increases transcriptional upregulation of the inflammatory cytokine interleukin 8 (IL-8) in a cell;
- (c) binds to p53;
- (d) degrades p53 in a cell;
- (e) binds to the WR domain of a different TWIST1 protein;
- (f) disrupts higher order TWIST1 complex formation in vitro or in a cell;
- (g) decreases TWIST1 function associated with cancer;
- or,
- (h) abrogates TWIST1 activity in vitro or in a cell.
Dependencies are inferred from the claim text.