Modulating the endocannabinoid system to achieve desired health or wellness effects

A method for developing a plant-based formulation to achieve a health treatment which has been previously achieved by a cannabis-based agent, the method comprising:

• identifying the health treatment effect achieved by the cannabis-based agent, wherein the health treatment includes at least one of controlling immune response, pain relief, sleep regulation, controlling mood, regulation of eating, relief from an upset stomach, treating nicotine dependence, and allergy relief, and wherein the cannabis-based agent causes an endocannabinoid system (ECS) receptor effect which results in the health treatment effect;
• identifying the ECS receptor effect caused by cannabis-based agent, wherein the ECS receptor effect includes that the cannabis-based agent acts as at least one of a CB1 effector, a CB2 effector, a CB1 uptake inhibitor, a CB2 uptake inhibitor, or a TRPV1 effector;
• determining one or more non-cannabis plant-based agents which produce the ECS receptor effect, wherein the non-cannabis plant-based agent(s) include at least one of a source selected from the group consisting of a source of quercetin, a source of curcumin, a source b-caryophyllene, a source of 18b-glycyrrhetinic acid, a source of biochanin A, a source of Tanshinone IIA, and mixtures thereof;
• and
• formulating a plant-based formulation having an effective amount of the non-cannabis plant-based agents to produce the ECS receptor effect.