Modified oncolytic vaccinia viruses expressing a cytokine and a car-boxylesterase and methods of use thereof
AssigneeSillajen, Inc.
InventorsTae Ho Hwang, Nam Hee Lee, Euna Cho
Life of this patent
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Abstract
The present disclosure pertains to a compositions and combinations for simultaneous, separate or sequential use which comprises (a) an oncolytic vaccinia virus that expresses a cytokine and a carboxylesterase enzyme, and, preferably, (b) a cancer co-drug, and to their uses for the treatment of cancer.
Claims21
A composition comprising a recombinant Western Reserve strain oncolytic vaccinia virus that expresses a cytokine and a carboxylesterase enzyme and that does not express an active thymidine kinase, wherein the cytokine is interferon-beta-1 and the carboxylesterase enzyme is CES2 and wherein the recombinant Western Reserve strain oncolytic vaccinia virus comprises a functional B18R gene.
Dependencies are inferred from the claim text.