Glucans
AssigneeBiotec Pharmacon ASA
InventorsRolf Engstad, Thor Nøkland
Life of this patent
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Abstract
The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≥1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 30 to 44° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.
Claims17
A gel glucan product obtainable by
- a) heating an aqueous solution of soluble yeast glucan molecules to a temperature of 120° C. to 130° C. and holding the solution at that temperature for 10 to 30 mins;
- and
- b) cooling the glucan solution to a temperature of 35° C. to 50° C., over a time period of less than 80 minutes,
- wherein said glucan is present in said gel glucan product at a concentration of 1 to 6%, has a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol, and wherein said gel glucan product has a gel to sol melting temperature between 30° C. and 44° C.
Dependencies are inferred from the claim text.