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US 10,646,503 B2Granted
Isotopologues of 5-azacytidine
AssigneeCelgene Corporation
InventorsJohn F. Traverse, William W. Leong, Jeffrey B. Etter, Mei Lai, Jay Thomas Backstrom
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Abstract
The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.
Claims1
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Y3 is a hydrogen isotopically enriched with deuterium, and Y1, Y2, Y4, Y5, Y6 and are non-enriched hydrogen atoms.
Dependencies are inferred from the claim text.