Selective high-affinity polydentate ligands and methods of making such

A method of inhibiting the growth or proliferation of a cancer cell that expresses an HLA-DR10 marker, said method comprising:

• contacting said cancer cell with a selective high-affinity polydentate ligand (SHAL), wherein-the SHAL comprises the structure:
• wherein R1 is selected from the group consisting of COOH, a linker, an effector, and a linker attached to an effector, wherein:
• when R1 is a linker, the linker is polyethylene glycol, biotin, lysine, or a combination of polyethylene glycol and lysine;
• and
• when R1 is an effector, the effector is selected from:
• (a) avidin, streptavidin, neutravidin, a second SHAL, biotin, a liposome, micelle, thymidine kinase;
• boron, uranium, or
• a chelate comprising a metal isotope selected from the group consisting of 213Bi, 212Bi, 111In, 64Cu, 186Re, 188Re, 90Y, 67Cu, 169Er, 121Sn, 127Te, 142Pr, 143Pr, 198Au, 199Au, 161Tb, 109Pd, 165Dy, 149Pm, 151Pm, 153Sm, 157Gd, 159Gd, 166Ho, 172Tm, 169Yb, 177Lu, 175Yb, 105Rh, 111Ag, and Iodine-131;
• (b) doxorubicin, biotin or a chelator selected from the group consisting of DOTA, EDTA, DTPA, CDTA, EGTA, HBED, TTHA, HEDTA, TETA, 2-2-iminothiolane, 2-iminothiacyclohexane, or 2-imino-4-mercaptomethylthiolane with bound metal isotope;
• (c) a transduction peptide selected from the group consisting of oligoarginine, hexa-arginine, SV40 T antigen nuclear localization signal, the HIV Tat protein transduction domain, the integrin-binding peptide (RGD), the heparin-binding domain of vitronectin (VN peptide), antennapedia protein of Drosophila, VP22, lactosylated polylysine, poly-L-lysine, SGEHTNGPSKTSVRWVWD, SMTTMEFGHSMITPYKID, QDGGTWHLVAYCAKSHRY, MSDPNMNPGTLGSSHILW, SPGNQSTGVIGTPSFSNH, SSGANYFFNAIYDFLSNF, or GTSRANSYDNLLSETLTQ
• (d) a cytotoxin or cytotoxic agent selected from the group consisting of, Diptheria toxin, Pseudomonas exotoxin A, ricin, abrin, modeccin A, alpha sacrin, Pokeweed antiviral protein S, Pokeweed antiviral protein type II, curcin, crotin, gelonin, mitogillin, restrictocin, phenomycin, and enomycin;
• (e) an enzyme inhibitor selected from the group consisting of 4[[5-(Trifluoromethyl)pyridin-2-yl]oxy]phenyl]N-phenylcarbamate, (R)-2-[4-(5-chloro-3-fluoro-2-pyridyloxy)phenoxy]propionic acid, 2-(((3-chloro-5(trifluoromethyl)pyridin-2-yloxy)phenoxy)methyl)acrylate, 2-(((3-chloro-5(trifluoromethyl)pyridin-2-yloxy)phenyl)methyl)acrylate, 2-(((3-chloro-5(trifluoromethyl)pyridin-2-yloxy)phenyl)methyl) acrylonitrile, 3-(3-chloro-4-{[5-(trifluoromethyl)-2-pyridinyl]oxy}anilino)-3-oxopropanoic acid, Sethoxydim, Clethodim, 5-(Tetradecyloxy)-2-furoic acid, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid, 2-[4-(4-Chlorophenoxy)phenoxy]propanoic acid, (RS)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]propanoic acid, (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid, (RS)-2-{4[5-(trifluoromethyl)-2-pyridyloxy]phenoxy}propanoic acid, (RS)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoic acid, and (RS)-2-[4-(α, α, α-trifluoro-p-tolyloxy)phenoxy]propanoic acid;
• or
• (f) a radiosensitizer selected from the group consisting of photofrin, 1,2,4-benzotriazine-3-amino-1,4-dioxide, cisplatin, cis-dichlorodiamineplatinum, and 1,2-diamino-4-nitrobenzene)dichloroplatinum II.