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US 10,646,501 B2Granted
Reducing the reproductive capacity of mammals
AssigneeSenestech, Inc.
InventorsLorretta P. Mayer, Cheryl A. Dyer
Life of this patent
Estimating the term…
Abstract
Provided are compositions and methods for reducing the reproductive capacity of mammals. The compositions and methods involve the use and administration of (a) a diterpenoid epoxide comprising a triptolide skeleton and which causes ovarian follicle depletion in female mammals and (b) an organic diepoxide which causes ovarian follicle depletion in female mammals.
Claims15
A method of controlling the size of a population of non-human mammals, providing to a population of non-human mammals an effective amount of a composition comprising:
- (a) a diterpenoid epoxide or a salt thereof which causes ovarian follicle depletion in female mammals selected from the group consisting of triptolide, tripdiolide, 16-hydroxytriptolide, triptonide or a salt thereof, and
- (b) an organic diepoxide which causes ovarian follicle depletion in female mammals selected from the group consisting of 4-vinylcyclohexene diepoxide (VCD), glycerol diglycidyl ether, 3,4-epoxy-cyclohexyl-methyl-3,4-epoxycyclohexyl carboxylate, 1,4-cyclohexanedimethanol diglycidyl ether, ethylene glycol diglycidyl ether, resorcinol glycidyl ether and 1,4-butanediol diglycidyl ether,
- wherein the composition is in the form of an edible bait that can be consumed by the male and female non-human mammals and wherein (a) and (b) are present in an amount to synergistically reduce the reproductive capacity of the male and female non-human mammals while not otherwise negatively effecting general health of the male and female non-human mammals.
Dependencies are inferred from the claim text.