17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors
AssigneeCosmo Technologies Limited
InventorMara Gerloni
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Abstract
The present invention relates to certain cortexolone derivatives of formula (I) and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
Claims9
A method of treating a tumor disease in a subject in need thereof, comprising administrating to said subject a therapeutically effective amount of a compound of formula (I):
- wherein:
- R is C(O)—R1;
- R1 is hydrogen or a linear alkyl chain containing 2 to 5 carbon atoms;
- R′ is a linear alkyl chain containing 3 to 6 carbon atoms or an optionally substituted aryl group or an optionally substituted heteroaryl group;
- and
- wherein R1 and R′ are not the same, and
- wherein the tumor disease is an adenocarcinoma.
Dependencies are inferred from the claim text.