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US 10,646,495 B2Granted
Testosterone ester triglyceride formulations
AssigneeAntares Pharma, Inc.
InventorShaowei Ong
Life of this patent
Estimating the term…
Abstract
Testosterone ester triglyceride formulations, optionally further including adducts. Methods of in-situ control of the manufacture or formation of such adducts are also described.
Claims14
A testosterone ester adduct of Formula 3:
- wherein:
- R1 is an alkyl or alkenyl substituent which can be the same or different at each independent occurrence;
- R5 is an acyl group corresponding to an unsaturated fatty acid;
- G is a glycerol, monoglyceride, or diglyceride residue;
- n is 1, 2, or 3;
- and
- the testosterone residue is connected to an allylic or doubly allylic carbon of R5.
4 more elements
A pharmaceutical formulation for parenteral administration comprising a testosterone ester of Formula 1, a pharmaceutically acceptable carrier comprising a triglyceride of Formula 2, and a testosterone ester adduct of Formula 3 at a concentration of between 0.005 mg/ml and 25 mg/ml,
- wherein:
- R1 is at each independent occurrence an alkyl or alkenyl substituent;
- each of R2, R3, and R4 is an acyl group corresponding to a fatty acid selected from the group consisting of linoleic acid, oleic acid, palmitic acid, ricinoleic acid, linolenic acid, and stearic acid;
- R5 is an acyl group corresponding to an unsaturated fatty acid;
- G is a glycerol, monoglyceride, or diglyceride residue;
- n is 1, 2, or 3;
- and
- the testosterone residue in Formula 3 is connected to an allylic or doubly allylic carbon of R5.
5 more elements
Dependencies are inferred from the claim text.