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US 10,646,489 B2Granted
Compositions and methods for increasing energy metabolism
AssigneeNuSirt Sciences, Inc.
InventorsMichael Zemel, Antje Bruckbauer, Brooke Baggett
Life of this patent
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Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
Claims22
A method for treating obesity in a subject in need thereof comprising administering a composition comprising:
- (a) at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and beta-hydroxymethylbutyrate (HMB);
- and
- (b) a synergistically effective amount of a phosphodiesterase 5 (PDE 5) inhibitor, wherein the PDE 5 inhibitor comprises sildenafil.
Dependencies are inferred from the claim text.