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US 10,646,486 B2Granted
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
AssigneeGilead Sciences, Inc.
InventorsElizabeth M. Bacon, Zhenhong R. Cai, Jeromy J. Cottell, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Philip Anthony Morganelli, Hyung-Jung Pyun
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Abstract
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Claims20
A compound of Formula (Ia)
- or a pharmaceutically acceptable salt thereof, wherein:
- is selected from
- R1 is selected from C1-4 haloalkyl and C3-6 cycloalkyl;
- R3 is phenyl substituted with at least 3 R5 groups;
- and
- each R5 is independently selected from C1-3 alkyl and halogen.
3 more elements
A compound of Formula (la)
- or a pharmaceutically acceptable salt thereof, wherein:
- is selected from
- R1 is selected from H, C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl;
- R3 is phenyl substituted with at least 3 R5 groups;
- and
- each R5 is independently selected from C1-3 alkyl and halogen.
3 more elements
Dependencies are inferred from the claim text.