Composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition
AssigneeOregon State University
InventorsOlena Taratula, Oleh Taratula, Adam Alani
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Abstract
Embodiments of a composition comprising a photosensitive compound and a polymer nanoparticle are disclosed herein. The composition may further comprise a targeting moiety. In some embodiments, the photosensitive compound is a phthalocyanine or phthalocyanine derivative, such as a naphthalocyanine. Upon irradiation with near infrared light, the composition may be used as a fluorescent imaging agent and/or as a phototherapeutic agent, such as for photodynamic and/or photothermal therapies. In certain embodiments, the composition is used to treat certain cancers.
Claims18
A composition, comprising:
- a polymer nanoparticle comprising a mPEG-5k-PCL-10k block copolymer;
- and
- a photosensitive compound encapsulated within the polymer nanoparticle, the photosensitive compound having a formula
- wherein R1-R32 are hydrogen;
- and
- M is silicon substituted with two —O—Si(C2-10alkyl)3.
A composition, comprising:
- a polymer nanoparticle comprising a mPEG-5k-PCL-10k block copolymer;
- and
- a photosensitive compound having a structure
- encapsulated within the polymer nanoparticle, the photosensitive compound being loaded into the nanoparticle at a concentration of from 0.4 mg/mL to 2 mg/mL.
Dependencies are inferred from the claim text.