US 10,646,469 B2 · Substituted indole derivatives as dengue viral replication inhibitors

Abstract

The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Claims7

Dependent claims

A compound selected from the group consisting of:

formula (Ia or Ib)
a stereoisomeric form, a pharmaceutically acceptable salt, solvate and polymorph thereof comprising a mono- or di-substituted indole group;
said compound is selected from the group wherein:
R1 is CF3 or OCF3, R2 is H or OCH3 or F, R3 is H;
and when R2 is H then R3 can also be CH3.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/087,800Filed 31 Mar 2017

Priority

EP 1616331231 Mar 2016

Published

US 2019/0274999 A112 Sep 2019

Granted

12 May 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
A61P 31/14
Antivirals: for RNA viruses
C07D 209/12
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by oxygen atoms
C07D 209/14
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by nitrogen atoms, not forming part of a…

Substituted indole derivatives as dengue viral replication inhibitors

Life of this patent

Substituted indole derivatives as dengue viral replication inhibitors

Life of this patent

Abstract

Claims7