Composition comprising tetracyclic compound
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKentaro Furumoto, Koji Shiraki, Tomoaki Hirayama
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Abstract
A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.
Claims4
A composition comprising 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile,
- or a salt thereof, a pharmaceutically acceptable carrier, and a dissolution aid,
- wherein the dissolution aid is selected from the group consisting of citric acid, hydroxypropylmethyl cellulose, methacrylic acid copolymer LD, methyl cellulose, purified shellac, sodium dehydroacetate, fumaric acid, DL-malic acid, L-aspartic acid, adipic acid, propylene glycol alginate ester, sodium caseinate, carboxymethylethyl cellulose, succinic acid, copolyvidone, dioctyl sodium sulfosuccinate, lactic acid, aluminum lactate, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose acetate succinate, sodium polystyrene sulfonate, polyvinylacetal diethylaminoacetate, methacrylic acid copolymer S, sulfuric acid, aluminum sulfate, a vinyl pyrrolidone×vinyl acetate copolymer, and sodium decyl sulfate.
Dependencies are inferred from the claim text.