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AssigneeNational Cancer Center
InventorsSeok Gu Kang, Jong Hee Chang, Eui Hyun Kim, Ji Hyun Lee, Yun Hee Jo, Junseong Park, Jin Kyoung Shim, Soo Youl Kim
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The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer.
A method for inhibiting growth of brain cancer stem cells in a subject suffering from brain cancer, comprising administering gossypol and phenformin to the subject, wherein the administration of gossypol and phenformin has a synergistic anti-cancer effect.
Dependencies are inferred from the claim text.