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US 10,646,451 B2Granted
GM3 functionalized nanoparticles
AssigneeTrustees of Boston University
InventorsBjoern Markus Reinhard, Suryaram Gummuluru
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Abstract
Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
Claims17
A nanoparticle comprising:
- a) a biodegradable core having a largest diameter between 50-90 nm;
- b) a coating layer encasing the biodegradable core, wherein the biodegradable core comprises a material selected from the group consisting of silica, mesoporous silica, polystyrene, titania, polyhydroxyalkanoates, polylactic acid (PLA), polybutylene succinate (PBS), polycaprolactone (PCL), polyanhydrides, polyvinyl alcohol, and cellulose esters;
- and
- c) a ganglioside GM3-containing mixed lipid layer comprising of dipalmitoylphosphatidylcholine (DPPC), cholesterol, phosphatidylserine (PS), and aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer (GM3);
- wherein the ganglioside GM3-mixed lipid layer is exterior of the coating layer and is integrated into the coating layer, and wherein the nanoparticles have an overall particle size between 60-100 nm.
2 more elements
Dependencies are inferred from the claim text.