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US 10,646,446 B2Granted
Pharmaceutical compositions containing a DGAT1 inhibitor
AssigneeNovartis AG
InventorsHong Wen, Natrajan Kumaraperumal, Richard Nause
Life of this patent
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Abstract
The present invention relates to a pharmaceutical composition comprising a) a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, b) one or more, e.g. 1, 2 or 3, surfactants with lubricant properties; c) one or more, e.g. 1, 2 or 3, dry binders with disintegrant properties; d) one or more, e.g. 1, 2 or 3, fillers, and e) one or more, e.g. 1, 2 or 3, disintegrants.
Claims8
A pharmaceutical composition in the form of a tablet with an optional film coating comprising:
- a) a therapeutically effective amount of the sodium salt of the compound trans-(4-{4-[5-(6-trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid of formula (I):
- b) 2 to 5% of sodium lauryl sulfate by weight of the tablet prior to the optional film coating and based on the free acid of the compound of the formula (I);
- c) 10 to 20% of low substituted hydroxypropyl cellulose (L-HPC-21), by weight of the tablet prior to the optional film coating and based on the free acid of the compound of the formula (I);
- d) 15-26% of microcrystalline cellulose by weight of the tablet prior to the optional film coating and based on the free acid of the compound of the formula (I);
- e) 0.1-1.0% of colloidal silica by weight of the tablet prior to any optional film coating and based on the free acid of the compound of the formula (I);
- f) 0.5-3% of sodium stearyl fumarate by weight of the table prior to the optional film coating and based on the free acid of the compound of the formula (I);
- g) 20 to 85% of anhydrous lactose by weight of the tablet prior to the optional film coating and based on the free acid of the compound of the formula (I);
- and
- h) 2 to 10% of sodium starch glycolate by weight of the tablet prior to the optional film coating and based on the free acid of the compound of the formula (I).
6 more elements
Dependencies are inferred from the claim text.