Analysis compensation including segmented signals converted into signal processing parameters for describing a portion of total error

A biosensor system for determining an analyte concentration in a biological fluid sample, the biosensor system being an optical system or an electrochemical system, the biosensor system comprising:

• a test sensor having a base and a sample interface, the base forming a reservoir and a channel with an opening, the opening being configured to receive the biological fluid sample and to allow the biological fluid sample to flow through the channel to fill at least in part the reservoir, the reservoir being in electrical or optical communication with the measurement device, the test sensor having a chemical reagent reacting in a chemical reaction with the analyte in the biological fluid sample when the biological fluid sample is received in the reservoir;
• a measurement device in electrical or optical communication with the reservoir, the measurement device having electrical circuitry communicatively coupled to a processor, a storage medium, a signal generator, and a sensor interface, the processor having instructions and data stored in the storage medium, the instructions configured such that when executed by the processor the system is enabled so that:
• in response to the chemical reaction in the reservoir, the signal generator applies an electrical or optical input signal to the sensor interface, the input signal including at least one excitation having a time period with an end-point,
• the input signal is transmitted by the sensor interface to the sample interface for applying the input signal to the biological fluid sample,
• in response to the input signal and to the concentration of the analyte in the biological fluid sample, the processor generates one or more output signals from the test sensor during an excitation period,
• the processor segments the one or more output signals during the excitation period of the one or more output signals into at least two segments with a regular or irregular segmenting interval, each segment including point readings obtained before the end-point of the input signal during the excitation period;
• the processor converts the one or more output signals of the at least two segments into at least two signal processing parameters, wherein the segmented signal processing parameters describe a portion of a total error in the one or more output signals;
• the processor determines a segmented signal processing function from the signal processing parameters;
• the processor uses a predetermined reference correlation to relate the one or more output signals to a plurality of known sample analyte concentrations;
• in response to the predetermined reference correlation, the processor uses a conversion function to convert the one or more output signals into one known sample analyte concentration of the plurality of known sample analyte concentrations;
• the processor determines a compensated value from the one or more output signals in response to the conversion function and the segmented signal processing function;
• the processor determines the analyte concentration in the biological fluid sample from the compensated value of the one or more output signals;
• and
• the processor outputs the analyte concentration to one or more of a display, a remote receiver, or a storage medium.

A method of operating a biosensor system for determining an analyte concentration in a biological fluid sample, the biosensor system being an optical sensor system or an electrochemical sensor system, the biosensor system including a measurement device and a test sensor, the measurement device having a processor, the test sensor being in electrical or optical communication with a reservoir, the method using the processor in performing steps comprising:

• receiving the biological fluid sample in the reservoir of the test sensor, the biological fluid sample including the analyte;
• applying an input signal to the biological fluid sample, the input signal including an excitation;
• generating during an excitation period, via the biosensor system, an output signal responsive to the input signal and further responsive to the concentration of the analyte, the output signal being one or more of a light-generated output signal in response to a light-identifiable species and an electrical output signal generated by a redox reaction;
• segmenting the output signal during the excitation period of the excitation into at least two segments, each segment including point readings obtained before an end-point of the excitation period;
• converting the at least two segments into at least two signal processing parameters, the signal processing parameters describing a portion of a total error in the output signal;
• determining a segmented signal processing function from the signal processing parameters;
• determining a compensated value from the output signal in response to the segmented signal processing function;
• determining the analyte concentration from the compensated value of the output signal;
• and
• outputting the analyte concentration to one or more of a display, a remote receiver, or a storage medium.