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US 10,646,438 B2Granted
Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine
AssigneeBoard of Regents, The University of Texas System
InventorsMaria A. Croyle, Jin Huk Choi, Stephen Clay Schafer
Life of this patent
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Abstract
Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.
Claims17
A composition comprising an amorphous, substantially solid film having an average thickness of 0.05 to 5 mm, which is soluble in an aqueous solution, said film comprising a virus that encodes a heterologous polypeptide, a sugar or sugar derivative or combination thereof, and poly(maleic anhydride-alt-1 octadecene).
A method comprising:
- (a) providing a virus that encodes a heterologous polypeptide and a solution comprising:
- (i) poly(maleic anhydride-alt-1 octadecene);
- and
- (ii) a sugar, sugar derivative or combination thereof;
- (b) dispersing the virus within the solution at ambient temperatures to form a mixture;
- and
- (c) drying the mixture at ambient temperatures so as to form an amorphous solid.
4 more elements
Dependencies are inferred from the claim text.