Hypotonic microbicidal formulations and methods of use
AssigneeThe Johns Hopkins University
InventorsKatharina Maisel, Craig W. Hendrix, Laura Ensign, Edward Fuchs, Richard Cone, Justin Hanes
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Abstract
Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing HIV infection, the microbicidal is tenofovir, or a prodrug or derivative thereof. The formulations may include additional agents such as surfactants to enhance cleansing, buffers, or preservatives. Polymers may be included for osmolarity as well as comfort.
Claims16
A hypotonic microbicidal composition comprising an effective amount of a microbiocide as a free drug to inhibit infection or replication, and a pharmaceutically acceptable carrier suitable for administration rectally or vaginally, wherein the composition has an effective osmolarity between 20 and 290 mOsm for tissue uptake at the rectal or vaginal site for a period of at least about 1 hour up to seven days following administration.
Dependencies are inferred from the claim text.