Intravenous administration of tramadol

A method of administering tramadol for treating acute postoperative pain in a human patient(s) via an intravenous dosing regimen, comprising

• intravenously administering a first dose of tramadol to a human patient(s) experiencing acute pain in an amount of about 60 mg;
• and thereafter intravenously administering additional doses of tramadol to the human patient(s) in an amount of about 60 mg tramadol at dosage intervals of about 6 hours, except that a second dose is intravenously administered as a loading dose at a shortened interval as compared to the dosage interval of about 6 hours, such that a total of 5 doses of 60 mg tramadol are intravenously administered on the first day of treatment and the intravenous tramadol is administered on subsequent days of treatment on a basis of a total of 4 doses of 60 mg tramadol per day until the intravenous tramadol administration is terminated, and wherein the tramadol is tramadol base or a pharmaceutically acceptable salt of tramadol, the dosing regimen providing a plasma level of tramadol which is similar to but does not substantially exceed the maximum (Cmax) plasma levels of tramadol obtained at steady-state by a 100 mg oral tramadol dose given every 6 hours prior to the end of the initial 24 hours of intravenous tramadol administration.

A method of administering tramadol for treating acute postoperative pain in a human patient(s) via an intravenous dosing regimen, comprising

• intravenously administering a first dose of tramadol to a human patient(s) experiencing acute pain in an amount of about 60 mg;
• and thereafter intravenously administering additional doses of tramadol to the human patient(s) in an amount of about 60 mg tramadol at dosage intervals of about 6 hours, except that a second dose is intravenously administered as a loading dose at a shortened interval as compared to the dosage interval of about 6 hours, such that a total of 5 doses of 60 mg tramadol are intravenously administered on the first day of treatment and the intravenous tramadol is administered on subsequent days of treatment on a basis of a total of 4 doses of 60 mg tramadol per day until the intravenous tramadol administration is terminated, and wherein the tramadol is tramadol base or a pharmaceutically acceptable salt of tramadol, such that the Cmax of the intravenous dosing regimen does not substantially exceed the concentration provided by 100 mg oral tramadol administered every 6 hours at steady-state by more than 15%.