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US 10,646,347 B2Granted
Protein delivery with porous metallic structure
AssigneeBioventus, LLC
InventorsJeffrey Welch, Eric Vanderploeg, Christopher Wilson, John Wozney
Life of this patent
Estimating the term…
Abstract
Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.
Claims35
A biocompatible implant, comprising:
- a matrix comprising nitinol (Ti—Ni) comprising a plurality of pores, wherein the matrix has a porosity of 58%-68% and the plurality of pores have a mean pore size between 50 and 500 microns;
- and
- an osteoinductive protein;
- wherein the pores are randomly distributed throughout the matrix.
1 more element
A biocompatible implant, comprising:
- a matrix comprising Ti—Ni comprising a plurality of pores, wherein the matrix has a porosity of 58%-68% and the pores have a mean pore size between 50 and 500 microns;
- and
- an osteoinductive protein comprising BMP-GER-NR, and
- wherein the pores are randomly distributed throughout the matrix.
1 more element
A biocompatible implant, comprising:
- a matrix comprising Ti—Ni comprising a plurality of pores, wherein the matrix has a porosity of 58%-68% and the pores have a mean pore size between 50 and 500 microns;
- and an osteoinductive protein comprising BMP-GER,
- wherein the pores are randomly distributed throughout the matrix.
A method of treating a patient, comprising the steps of:
- contacting a bony tissue of the patient with a biocompatible implant, said implant comprising:
- a matrix comprising Ti—Ni having a plurality of pores, wherein the matrix has a porosity of 58%-68% and the pores have a mean pore size between 50 and 500 microns;
- and
- an osteoinductive protein,
- wherein the pores are randomly distributed throughout the matrix.
2 more elements
A biocompatible implant, comprising:
- a matrix comprising Ti—Ni and a plurality of pores, wherein the matrix has a porosity of 58%-68% and the pores have a mean pore size between 50 and 500 microns;
- an osteoinductive protein, and wherein the pores are randomly distributed throughout the matrix;
- and
- a plurality of porous, calcium ceramic granules deposited within an open region of the matrix at a ratio of 150-310 milligrams of granules per cubic centimeter of matrix.
1 more element
Dependencies are inferred from the claim text.