Device, system and method for intermittent displacement of blood to mitigate peripheral nerve neuropathy

A system for mitigating peripheral nerve neuropathy associated with chemotherapy treatment, comprising:

• a compression exertion device having an interior space adapted for receiving an appendage of a patient, wherein the compression exertion device includes a sealing component engageable with at least one of a portion of the appendage and a limb to which the appendage is attached when the appendage is positioned within the interior space;
• and
• a pressure controller operably attached to the compression exertion device to cause a compression-inducing medium within the compression exertion device to exert compressive pressure on the appendage during at least a portion of a prescribed amount of delivery of a chemotherapeutic agent to the patient, wherein the pressure controller being operably attached to the compression exertion device to cause the compression-inducing medium within the compression exertion device to exert compressive pressure on the appendage includes causing at least one of a magnitude of the compressive pressure and a duration of time for the compressive pressure being exerted to at least partially occlude blood flow into dermis tissue of the appendage and wherein the pressure controller monitors administration of a chemotherapeutic agent to a patient to enable the compressive pressure to be provided as a function of said administration of the chemotherapeutic agent to the patient during a prescribed amount of delivery thereof.