iFR-CT

A system for non-invasively determining an instantaneous wave-free ratio metric, comprising:

• a storage medium;
• and
• at least one processor configured to:
• calculate peripheral resistances of outlets of the vessel from image data generated by an imaging system during a wave-free period of diastole, wherein the image data includes voxels with intensities representative of a vessel with a stenosis;
• calculate a stenosis resistance of the stenosis of the vessel between an inlet of the vessel and the outlets of the vessel based on a set of boundary conditions, a result of a computational fluid dynamics algorithm and the peripheral resistances;
• calculate the instantaneous wave-free ratio metric, wherein the metric is a numerical value that is based on the stenosis resistance;
• and
• generate a signal indicative of the calculated instantaneous wave-free ratio metric.

A non-transitory computer readable storage medium having one or more executable instructions stored thereon, which, when executed by at least one processor, cause the at least one processor to perform a method for non-invasively determining an instantaneous wave-free ratio metric by a data analyzer, the method comprising:

• receiving electronically formatted image data generated by an imaging system during a wave-free period of diastole, wherein the image data includes voxels with intensities representative of a vessel with a stenosis;
• computing peripheral resistances of outlets of the vessel from the image data;
• calculating a stenosis resistance of the stenosis between an inlet of the vessel and the outlets of the vessel based on a set of boundary conditions, a computational fluid dynamics algorithm and the peripheral resistances;
• calculating the instantaneous wave-free ratio metric, wherein the metric is a numerical value that is based on the stenosis resistance;
• and
• generating a signal indicative of the calculated instantaneous wave-free ratio metric.